This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator.It starts in the late 1960s when striking Seat Guide 2 rhythmic episodes of luteinizing hormone secretion, as reflected by circulating concentrations of this gonadotropin, were first observed in monkeys and ends
Biotechnological advancements and challenges in textile effluents management for a sustainable bioeconomy: Indian case studies
The textile industries role on imminent hazardous environmental impact has global attention.The remediation of textile effluent is often challenging because of the presence of a wide variety of pollutants like dyes, acids, bases, metal TV CUPBOARD salts, and microorganisms.The use of biological recycling methods are contemplated to mitigate the haz
Late-onset cluster seizures and intellectual disability associated with a novel truncation variant in SMC1A
SMC1A variants are known to cause Cornelia de Lange Syndrome (CdLS) which encompasses a clinical spectrum of glo intellectual disability, dysmorphic features (long or thick eyebrows, a hypomorphic philtrum and small nose) and, in some cases, epilepsy.More recently, SMC1A truncating variants have been described as the cause of a neurodevelopmental d